Definition Hereditary hemochromatosis is an inherited disorder that leads to iron overload due to excessive absorption of dietary iron because of a deficiency of hepcidin, which is an iron regulatory peptide hormone. A homozygous C282Y mutation in HFE is responsible…
43.1 Introduction 43.1.1 Liver Anatomy and Function The cell types within the liver consist of hepatocytes, biliary epithelial cells, sinusoidal-lining cells (Kupffer cells and endothelial cells), stellate cells (formerly known as Ito cells), and cells involved in the immune response.…
You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Secondary liver disease stemming from vascular pathology related to heart failure, portal vein obstruction, and Budd-Chiari syndrome represents clinically important conditions associated with significant morbidity and impairment of health-related quality of life. The Liver in Heart Failure Heart failure represents…
Systemic Amebiasis may be complicated by the development of an amebic liver abscess ( Fig. 179.1 ). Entamoeba histolytica (also known as E. histolytica ) represents the most common parasite identified in amebic liver abscess and is a commensal organism…
You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Hepatocellular carcinoma (HCC) represents one of the most important and life-threatening complications of chronic liver disease. The 5-year survival of patients with HCC remains sobering despite significant advances in the epidemiology, diagnosis, and management of this disease. The epidemiology of…
Wilson disease (WD) is a rare primary copper overload disorder which was first described in 1912 by the neurologist Samuel Kinnier Wilson as “progressive lenticular degeneration” associated with cirrhosis. However, it was not until 1948 that WD was recognized as…