Introduction Myocardial infarction (MI) is caused by atherothrombosis (see Chapter 3 ), with platelets playing a pivotal role in the initial onset of MI and its recurrence. Antiplatelet therapy targets this key element in the pathobiology of cardiovascular ischemic events.…
Introduction Myocardial infarction (MI) is defined by myocyte necrosis. If large in its territory or critical in its location, this injury can lead to loss of contractile function or other structural complications (see Chapter 26 ) that result in insufficient…
Introduction Chest symptoms suspicious for acute myocardial infarction (MI) are among the most common reasons for emergency evaluation, accounting for six to seven million emergency department (ED) visits each year in the United States. The initial assessment of nontraumatic chest…
Introduction Until the beginning of 20th century, it was believed that coronary thrombosis was always immediately fatal. In 1910, two Ukrainian physicians described five patients with acute myocardial infarction (MI), in whom three were found to have coronary thrombosis at…
Additional content is available online at Elsevier eBooks for Practicing Clinicians The spectrum of stable ischemic heart disease (SIHD) is broad and includes individuals with chronic stable angina, asymptomatic ischemia, prior myocardial infarction, and prior coronary revascularization, as well as…
Additional content is available online at Elsevier eBooks for Practicing Clinicians The care of patients with ST-elevation myocardial infarction (STEMI) has transformed in conjunction with the shift in approach to reperfusion therapy from primarily pharmacologic to catheter-based strategies. With simultaneous…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Myocardial infarction (MI) results from myocardial cell necrosis caused by an imbalance between oxygen supply and demand. Cardiac professional societies have jointly established criteria for the diagnosis of MI…