S-Adenosyl- l-Methionine

As an antiaging, antidisease therapeutic agent.

May protect against the hepatotoxic effect of certain drugs (e.g., alcohol, acetaminophen, phenobarbital, and steroids).

Depression, mild to moderate and adolescent.

Anxiety, PMS.

Heart disease.

Liver disease, cirrhosis, intrahepatic cholestasis, disorders of porphyrin, and bilirubin metabolism.

Osteoarthritis, tendinitis, bursitis, chronic low back pain.

Dementia, Alzheimer disease, Parkinson disease.

MS, migraine, seizure, spinal cord injury.

Chronic lead poisoning.

Disorder of porphyrin and bilirubin metabolism.

Chronic fatigue syndrome.

Intellectual enhancement, ADHD.

Postop SAMe therapy can benefit residual liver function of pts with cirrhosis, especially pts suffering marked ischemia reperfusion injury.

SAMe supplementation restores hepatic antioxidant glutathione (GSH) deposits. Depleted glutathione is associated with alcoholism, acetaminophen toxicity, Alzheimer disease, Crohn disease, diabetes, heart disease, and stroke.

N/V, flatulence, diarrhea, irregular or accelerated HR

Anxiety