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Rabeprazole
See also Proton pump inhibitors
General information
The benefit to harm balance of rabeprazole, a proton pump inhibitor, has been reviewed [ , ]. The overall rate of drug withdrawal because of adverse reactions was 3%. Common adverse reactions included diarrhea, headache, and rashes.
General adverse effects and adverse reactions
In short-term and long-term studies of up to 2 years, headache was the most important reported adverse reaction. Other commonly reported adverse reactions were diarrhea, rhinitis, nausea, pharyngitis, abdominal pain, and flatulence. The changes in serum gastrin concentrations were consistent with proton pump inhibitor pharmacology. In controlled trials, the frequency of abnormalities of hepatic aminotransferases was similar to that of placebo. Scoring of enterochromaffin-like cells in gastric biopsies taken prospectively from patients in studies of up to 2 years have shown some hyperplastic changes, but no evidence of adenomatous, dysplastic, or neoplastic changes.
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