Pentetrazol

General information

Pentetrazol (pentylenetetrazol) is a central and respiratory stimulant, similar to doxapram hydrochloride. It is a GABA _A receptor antagonist and is anxiogenic [ ]. It has been used in respiratory depression and has also been included in multi-ingredient formulations for respiratory tract disorders, including cough, and for the treatment of hypotension and pruritus. However, the general consensus is that pentetrazol does not have a place in the treatment of respiratory depression [ ]. It has also been used to provoke seizures during the use of SPET scanning to localize the epileptic focus as a diagnostic procedure in patients with drug-resistant epilepsy [ ].