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Pancreatic enzymes
General information
Pancreatic enzyme supplements are used to treat people who lack pancreatic secretions. Pancreatin is an extract of pancreas, and contains enzymes with proteinase, amylase, and lipase activity; most commercial formulations are similar or identical [ ].
Drug studies
Observational studies
The effect of oral pancreatic enzyme supplementation (Creon 10 000 in a dose of 1000 units of lipase per gram of ingested dietary fat) on fat malabsorption has been evaluated in an open study in 24 patients with HIV infection [ ]. Pancreatic enzyme supplementation was highly effective in reducing fecal fat loss. There were no clinical adverse reactions or adverse effects on serum biochemistry attributable to the drug.
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