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Atopy Redefined

Key points Although the original term atopy provides a general framework of understanding about allergic clinical conditions, this big umbrella now includes a group of patients who have heterogeneous clinical and laboratory-defined characteristics. Similarly, atopic dermatitis , the skin atopy, characterizes a group of patients with heterogeneous clinical and laboratory-based findings. Since the immune milieu in children is a dynamic system, atopic dermatitis manifested in childhood…

Historic Perspective

Key points From the historic perspective, atopic dermatitis has gone through several evolutionary periods of understanding and development. From ancient times to the 18th century, medical communities started to recognize a type of itchy skin disease. Although the term eczema had been used, no unified concept had been developed and no understanding of its underlying pathophysiology was established. The 19th century witnessed the rapid development of…