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Soft Tissue Masses of the Extremities

Introduction Optimal management of extremity soft tissue masses requires an understanding of soft tissue sarcoma biology. The goal of the clinical evaluation is to discern local signs and symptoms concerning for malignancy as well as any relevant predisposing factors. Further evaluation proceeds based on the degree of suspicion of malignancy. Small masses without concerning clinical features are likely benign and can be observed. Masses that are…

Familial Breast Cancer

Hereditary Breast and Ovarian Cancer Syndrome Testing Criteria 1. A known mutation in a cancer susceptibility gene in the family, such as BRCA1 or BRCA2 2. An individual with breast cancer meeting one of the following criteria: a. Diagnosed ≤ 45 years of age b. Diagnosed ≤ 50 years of age with one of the following additional criteria: (i) an additional breast cancer primary, (ii) ≥1…