D efinition — Endometrial adenocarcinoma which has spread caudally to involve the cervix. Clinical Features Epidemiology Varies with the subtype of endometrial adenocarcinoma. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

D efinition — Serous carcinoma originating from the upper genital tract involving the cervix (drop metastasis). Clinical Features Epidemiology Uncommon. Women in their 60s to 70s. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

D efinition — An increase in the number of endocervical glands. May be idiopathic or secondary to increased hormonal stimulation. Some atypical hyperplasias may be associated with minimal deviation adenocarcinomas and Peutz-Jeghers syndrome (see page 300 ). Clinical Features Epidemiology Usually seen in reproductive-age women as an incidental finding. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become…

D efinition — The histologic appearance of large prostatic duct–like tissue within the cervical stroma. Clinical Features Epidemiology Prostatic metaplasia is a rare (or possibly under-reported) process. There is no age predilection. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

D efinition — A carcinoma derived from mesonephric remnants located in the lateral walls of the uterine cervix. Clinical Features Epidemiology Very rare. The mean age at presentation is early 50s. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

D efinition — Embryologic remnants of mesonephric differentiation found in the gynecologic tract. Clinical Features Epidemiology Mesonephric remnants may be identified in up to one fifth of well-sampled cervices. No age or demographic predilection has been identified. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

D efinition — Adenocarcinoma composed of basaloid cells with areas of columnar cell differentiation. Clinical Features Epidemiology Rare; accounts for less than 5% of cervical carcinomas. Usually seen in postmenopausal women. Human papillomavirus (HPV) associated. African-American women are affected more than other ethnicities. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member.…

D efinition — A rare variant of invasive adenocarcinoma originating in the endocervix. Clinical Features Epidemiology Limited to case reports. Wide age range, but most present in the fourth or fifth decade. Human papillomavirus (HPV) associated. May be found with other adenocarcinomas such as usual type of adenocarcinoma or neuroendocrine carcinoma (rare cases). You’re Reading a Preview Become a Clinical Tree membership for Full access and…

D efinition — A carcinoma resembling an upper genital tract serous carcinoma but originating in the cervix and usually human papillomavirus (HPV) related. Clinical Features Epidemiology Rare. There is a distinctly bimodal age distribution; most patients are under age 45, but there is a second smaller peak after age 65. As a rule of thumb, for cases in older women a metastasis from the endometrium, tube,…

D efinition — A deceptively bland-appearing mucinous adenocarcinoma of the cervix. Atypical lobular endocervical glandular hyperplasia (ALGH) is considered a potential precursor to minimal deviation adenocarcinoma (MDA). Clinical Features Epidemiology Uncommon. Not associated with human papillomavirus (HPV). Reproductive-age women; mean age at diagnosis is 42 years. Associated with Peutz-Jeghers syndrome (10% to 15% of cases). Presentation Vaginal bleeding and/or discharge. Firm, indurated cervix (barrel cervix). Some…

D efinition —A unique, typically HPV-negative adenocarcinoma that has been associated with prenatal diethylstilbestrol exposure. Clinical Features Epidemiology Rare. Historically linked to diethylstilbestrol (DES) exposure in utero. Sporadic occurrences now much more frequent than DES-related cases. Wide age range, with a mean age of 45 to 50 years, but case reports include occurrences in children and adolescents. You’re Reading a Preview Become a Clinical Tree membership…

D efinition — Invasive adenocarcinoma originating in the endocervix. Clinical Features Epidemiology Average age at diagnosis is early 40s. Human papillomavirus (HPV) associated. A positive association with oral contraceptive use has been noted, but the mechanism is not understood. Not associated with tobacco use. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a…

D efinition —A florid pattern of endocervical adenocarcinoma in situ (AIS) that mimics invasive adenocarcinoma. Clinical Features Epidemiology The same as for conventional AIS. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

D efinition — Early-stage invasive endocervical adenocarcinoma. Clinical Features Epidemiology Average age at diagnosis is early 40s. Human papillomavirus (HPV) associated. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

D efinition — A well-differentiated adenocarcinoma with a major exophytic and villoglandular component. Clinical Features Epidemiology Wide age range (third to seventh decades) with a mean age of 38 years. Human papillomavirus (HPV) associated. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

D efinition — Changes seen in the cervical-vaginal epithelium following radiation therapy. Clinical Features Epidemiology A common finding in tissue samples following radiation therapy to the genital area. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

D efinition — A multinucleated endocervical cell atypia commonly associated with chronic inflammation. Clinical Features Epidemiology Relatively common, occasionally pronounced. Typically reproductive age, but can occur at any age. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

D efinition — Hormonally driven benign morphologic alteration of the endocervical epithelium, most commonly associated with pregnancy or the recent postpartum state. Clinical Features Epidemiology Endocervical Arias-Stella effect may be seen in up to 50% of extensively examined gravid cervices. Occasionally a rare, focal finding in nonpregnant women. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership…

D efinition — Ectopic endometrial glands and stroma (endometriosis) or endometrial stroma in isolation (stromatosis). Clinical Features Epidemiology Endometriosis is common. Seen across all ages and demographic groups. Often follows punch or cone biopsy presumably because endometrial tissue colonizes the exposed stroma. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log…