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Fractures account for 10–15% of all childhood injuries. The anatomic, biomechanical, and physiologic differences in children account for unique fracture patterns and management. Fracture terminology helps describe fractures ( Table 198.1 ). Table 198.1 Useful Fracture Terminology Complete The bone fragments separate completely Incomplete The bone fragments are still partially joined Linear Referring to a fracture line that is parallel to the bone’s long axis Transverse…
It is important to understand the growth and development of the musculoskeletal system as well as common orthopedic terms ( Table 197.1 ). Providers should recognize common mechanisms for congenital and acquired orthopedic disorders ( Table 197.2 ). Table 197.1 Common Orthopedic Terminology ABDUCTION MOVEMENT AWAY FROM MIDLINE Adduction Movement toward or across midline Apophysis Bone growth center that has a muscular insertion but is not…
Chapter 188 Dermatology Assessment Common cutaneous conditions in pediatrics include atopic dermatitis, impetigo, tinea capitis, acne vulgaris, verrucae vulgaris, and seborrheic dermatitis. Obtaining a thorough history including the age of the patient, onset, duration, progression, associated cutaneous symptoms (pain, pruritus), previous treatments, and associated systemic signs or symptoms (fever, malaise, weight loss) is important. Characterizing and describing the primary and secondary skin lesions is important for…
Arthropods are common in the environment. Although many can bite or sting humans, only a few infest humans. Arachnids (mites) are the most common, parasitizing humans and animals by burrowing into the skin and depositing eggs within the skin. Scabies Scabies is caused by the mite Sarcoptes scabiei . The female mite burrows into the epidermis and deposits her eggs, which mature in 10–14 days. The…
Erythema multiforme (EM), reactive infectious mucocutaneous eruption (RIME), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are acute hypersensitivity reactions characterized by cutaneous and mucosal necrosis. These syndromes represent a hypersensitivity reaction to a precipitating cause, usually infectious organisms or drugs. These disorders were historically thought to represent a spectrum of the same disease process, and inconsistent use of these disease names led to further confusion.…
Vascular anomalies can be divided into two major categories: tumors and malformations. Vascular tumors are characterized by hypercellularity, proliferation, and growth. Vascular malformations, however, are developmental defects derived from the capillary, venous, arterial, or lymphatic vessels. In contrast to hemangiomas, vascular malformations remain relatively static and grow very slowly over time. Differentiating between these entities is important because they have different prognoses and clinical implications. Vascular…
Birthmark is a term that describes congenital anomalies of the skin. It should not be used as a definitive diagnosis because congenital skin lesions vary greatly in their appearance and prognosis. The differential diagnosis of various birthmarks is listed in Table 193.1 . Table 193.1 Common Birthmarks COLOR/LESION BIRTHMARK LOCATION OTHER FEATURES Brown/macule or patch Café-au-lait macule Variable May be associated with genetic syndromes Brown (<40…
Etiology Seborrheic dermatitis is a common, chronic inflammatory disease that has different clinical presentations at different ages. Seborrheic dermatitis classically presents in infants as cradle cap or dermatitis in the intertriginous areas of the axillae, groin, antecubital and popliteal fossae, and umbilicus. It is seen in adolescents as dandruff. The pathogenesis of seborrheic dermatitis is unclear, but it is theorized that there is an abnormal inflammatory…
Etiology and Epidemiology Inflammation in the top layers of the skin, caused by direct contact with a substance, is divided into two subtypes: irritant contact dermatitis and allergic contact dermatitis. Irritant contact dermatitis is observed after the skin surface is exposed to an irritating chemical or substance. Contact dermatitis may occur in any age, and girls are more frequently affected than boys. Allergic contact dermatitis is…
Etiology Atopic dermatitis is a chronic inflammatory disease with no known cure. It is associated with significant psychosocial morbidity and decreased health-related quality of life. For many affected individuals, atopic dermatitis is the skin manifestation of atopy accompanied by asthma and allergic rhinitis. Atopic dermatitis manifests with a defective skin barrier, reduced innate immune responses, and exaggerated immune responses to allergens and microbes. Both genetic predisposition…
Etiology Acne vulgaris (or acne) is a chronic inflammatory disorder that affects areas with the greatest concentration of sebaceous glands, such as the face, chest, and back. Gender, age, genetic factors, and environment are all major contributing pathogenic factors. Stress may trigger acne, possibly by affecting hormone levels. A high glycemic diet and milk intake, low-fat/skim milk in particular, may be associated with acne, although they…
Approximately one in three Americans of any age has at least one recognizable skin disorder at any time. The most common cutaneous diseases encountered in community settings are dermatophytosis, acne vulgaris, seborrheic dermatitis, atopic dermatitis (eczema), verrucae (warts), tumors, psoriasis, vitiligo, and infections such as herpes simplex and impetigo. The most common diagnoses in children attending pediatric dermatology clinics include atopic dermatitis, seborrheic dermatitis, impetigo, tinea…
General information Repirinast is an antiallergic prodrug which is de-esterified to an active metabolite that has a stabilizing action on mast cells resembling that of sodium cromoglicate [ ]. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
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See also Opioid receptor agonists General information Remifentanil is a pure μ opioid (OP 3 , MOR) receptor agonist with a very short duration of action. It therefore has to be given by continuous intravenous infusion and is used as a supplement to general anesthesia during induction and as an analgesic during maintenance of anesthesia. It causes the same adverse reactions as other opioid agonists: respiratory…
General information Remacemide hydrochloride is a low-affinity, non-competitive N-methyl- d -aspartate (NMDA) receptor blocker that has been used in epilepsy, Parkinson's disease, Huntington's chorea [ ], and neuroprotection after stroke [ ]. Its pharmacology, clinical pharmacology, uses, and adverse reactions and interactions have been reviewed [ , ]. However, there appear to be no current clinical studies of this drug and there have been no publications…
General information Reboxetine is a selective noradrenaline re-uptake inhibitor with low affinity for α-adrenoceptors and muscarinic receptors [ ]. In controlled trials the following adverse events occurred significantly more often with reboxetine than with placebo: dry mouth (27%), constipation (17%), increased sweating (14%), insomnia (14%), urinary hesitancy (5%), impotence (5%), tachycardia (5%), and vertigo (2%) [ ]. Organs and systems Endocrine Pseudopheochromocytoma has been attributed to…
General information Razaxaban, a selective oral direct factor Xa inhibitor [ , ], was discontinued by the manufacturer after the three higher doses in a dose-ranging study in venous thromboembolism caused an increased risk of bleeding. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
See also Antifungal azoles [for systemic use] General information Ravuconazole is an antifungal azole, similar in structure to fluconazole. It has a long half-life suitable for once-daily dosing. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
General information Rasburicase is recombinant urate oxidase, which causes the breakdown of uric acid to 5-hydroxyisourate, which is further broken down to allantoin. Although there is a gene for urate oxidase in human, it is non-functional, and purine catabolism therefore ends with uric acid. This may be advantageous, because uric acid is an antioxidant. In the root nodules of legumes urate oxidase is necessary for nitrogen…