Manidipine

General information

Manidipine is a dihydropyridine calcium channel blocker that can be given once a day for hypertension. In a comparison of manidipine 10 mg/day and amlodipine 5 mg/day in a multicenter, randomized, double-blind study in 530 patients with mild-to-moderate hypertension, the two drugs had comparable antihypertensive effects, but manidipine was associated with a significantly lower incidence of ankle edema [ ]. Nevertheless, adverse events caused withdrawal from treatment in a similar number of patients, 23 with manidipine and 26 with amlodipine.

Organs and systems