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Malignant nephrosclerosis


Definition

  • A clinicopathological syndrome characterized by a thrombotic microangiopathy induced by severe hypertension (systolic pressure greater than 220 mm Hg or diastolic pressure greater than 120 mm Hg)

Clinical features

Epidemiology

  • The average age at diagnosis is 40 years, and men are affected more often than women.

  • Cigarette smokers, African Americans, and patients with underlying chronic renal disease are at higher risk.

  • Fifty percent have a history of benign nephrosclerosis.

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