Levobupivacaine

General information

Levobupivacaine is the levorotatory isomer, S(−)-bupivacaine, of bupivacaine, an amide local anesthetic.

In a comparison of the clinical efficacy of epidural S(−)-bupivacaine with standard racemic RS-bupivacaine in 88 patients S(−)-bupivacaine was clinically indistinguishable from RS-bupivacaine in the three groups studied (0.75% or 0.5% S(−)-bupivacaine and 0.5% RS-bupivacaine). Hypotension was distributed evenly across the groups and five patients complained of minor neurological abnormalities (hypesthesia and paresthesia), which resolved quickly after the operation [ ].

Organs and systems