Lesopitron

General information

Lesopitron is a non-benzodiazepine anxiolytic drug. Its structure is similar to that of buspirone, and it is an agonist at central serotonin (5-HT _1A ) receptors [ ].

In a 6-week, double-blind, randomized, parallel, phase II, single-center, outpatient comparison of lesopitron 40–80 mg/day, lorazepam 2–4 mg/day, and placebo in 161 patients with generalized anxiety disorder, the most common adverse events associated with lesopitron were somnolence, headache, and dyspepsia, compared with headache, somnolence, and insomnia with lorazepam [ ]. Patients treated with placebo mainly experienced headache, somnolence, and pharyngitis.