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Ifosfamide
See also Cytotoxic and immunosuppressant drugs
General information
Ifosfamide is an alkylating agent belonging to the group of oxazaphosphorines. It is used to treat a variety of solid tumors in children, including rhabdomyosarcoma, soft tissue sarcomas, Wilms’ tumor, bone sarcomas, and neuroblastoma, and leukemias and lymphomas in adults. It is also sometimes used in combination with other drugs, such as doxorubicin or cisplatin and etoposide.
Organs and systems
Cardiovascular
Atrial fibrillation has been attributed to ifosfamide after a dose of only 1800 mg/m 2 , with mesna, in a regimen for metastatic breast cancer [ ].
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