Hormonal ablation-induced changes


  • Androgen deprivation therapy is a popular form of treatment for prostate cancer.

  • Androgen deprivation can be achieved with multiple methods:

    • Orchiectomy

    • Estrogen

    • Gonadotropin-releasing hormone antagonists (luteinizing hormone–releasing hormone [LH-RH] agonists)

    • Anti-androgen

    • 5α-reductase inhibitors

  • Agents are used for preoperative tumor shrinkage, symptomatic relief of metastases, cancer prophylaxis, and treatment of hyperplasia.

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