Hormonal ablation-induced changes

Definition

• Androgen deprivation therapy is a popular form of treatment for prostate cancer.

• Androgen deprivation can be achieved with multiple methods:

  • Orchiectomy

  • Estrogen

  • Gonadotropin-releasing hormone antagonists (luteinizing hormone–releasing hormone [LH-RH] agonists)

  • Anti-androgen

  • 5α-reductase inhibitors

• Agents are used for preoperative tumor shrinkage, symptomatic relief of metastases, cancer prophylaxis, and treatment of hyperplasia.

Clinical features