Genaconazole

General information

Genaconazole is an N-substituted triazole with a wide antifungal spectrum. Its absorption is slow, with peak concentrations 2–4 hours after a single dose and mean peak concentrations markedly higher after 16 days of administration. The half-life is about 90–100 hours [ ]. It has high tissue penetration, including the CNS, and good broad-spectrum antifungal activity. However, it causes hepatocellular carcinoma in animals and the manufacturers stopped developing it because of concerns about toxicity.