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Flutamide
See also Antiandrogens
General information
Flutamide is a non-steroidal antiandrogen that is used to treat prostatic cancer. Its most common adverse reactions are liver damage and photosensitivity.
Drug studies
Comparative studies
Prostate cancer
Although flutamide is sufficiently well tolerated in prostatic cancer, the much older drug cyproterone acetate continues to show up favorably. In a direct comparison between the two drugs in 310 men the two were equally effective in delaying progression of the cancer and prolonging survival; however, adverse reactions profiles were more favorable for cyproterone acetate overall and in particular with respect to gynecomastia, diarrhea, and nausea [ ].
Polycystic ovary syndrome
In 44 women with polycystic ovary syndrome treated with finasteride or flutamide for 6 months the adverse reactions to flutamide were reduced libido, gastrointestinal disorders, and dry skin [ ]. Finasteride caused reduced libido, headache, and dry skin. Dry skin was reported in 68% of users of flutamide and in only 27% of users of finasteride.
Organs and systems
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