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Feprazone
See also Non-steroidal anti-inflammatory drugs (NSAIDs)
General information
Feprazone is an NSAID that is related to phenylbutazone. It was withdrawn in the UK because of adverse reactions, which resemble those of phenylbutazone. It was designated as a last-resort drug by the Japanese Committee on Safety of Drugs [ ].
In an 8-week trial in 2693 patients with rheumatoid arthritis and osteoarthritis, 30% reported adverse effects and 11% failed to complete the study. However, two large short-term multicenter studies in general practices in 11 000 patients in Italy reported a very low percentage (1.2–9.8%) of adverse reactions [ , ].
Gastrotoxicity, nephrotoxicity, edema, headache, tinnitus, and depression have been attributed to feprazone [ ].
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