Deoxyspergualin

General information

Deoxyspergualin is a synthetic analogue of the immunosuppressive anti-tumor antibiotic spergualin. It contains the polyamine spermidine as part of its structure and has similar properties and mechanisms of action to ciclosporin and the calcineurin inhibitors. It has been used as an immunosuppressant in preventing and treating graft rejection [ ], in vasculitis [ , ] proliferative glomerulonephritis [ ] and systemic lupus erythematosus [ ], and in patients with various types of cancers [ ].