Choline and choline alfoscerate

General information

Choline has been given in the past as an acetylcholine precursor to raise acetylcholine concentrations in the brain and thus enhance cholinergic neurotransmission. Choline alfoscerate increases cerebral acetylcholine synthesis and release [ ]. In the light of animal studies it has been investigated as a possible treatment for vascular dementia [ ]. There is evidence that the symptoms of tardive dyskinesia can be reduced by choline or lecithin [ ].

Large amounts of choline, and or phosphatidylcholine have been used to treat various neurological conditions, to prevent hypercholesteremia and atherosclerosis, and to restore memory and cognition. High doses of lecithin and choline can cause acute gastrointestinal distress, sweating, salivation, and anorexia [ ].