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Chloroprocaine
See also Anesthetics, local
General information
Chloroprocaine is a local anesthetic, an aminoester of para-aminobenzoic acid. Its systemic toxicity is low, owing to rapid hydrolysis by plasma pseudocholinesterases [ ].
Drug studies
Comparative studies
Chloroprocaine was compared with lidocaine in a double-blind, randomized, crossover study [ ]. Eight healthy volunteers each received two spinal anesthetics, one with 2% lidocaine (40 mg) and the other with 2% chloroprocaine (40 mg). Chloroprocaine produced an anesthetic effect similar to that of lidocaine, but with significantly faster resolution of the block. In seven of the eight subjects lidocaine produced mild transient neurological symptoms, whereas in the chloroprocaine group there were no such complaints.
Organs and systems
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