Etiology Fungal infections of the chest can be divided into two groups based on pathogenesis. The first group is composed of endemic fungi, including Histoplasma capsulatum, Coccidioides immitis, Blastomyces dermatitidis, and Cryptococcus gattii , and the second group is composed…
A variety of nontuberculous mycobacteria (NTMB) can cause pulmonary infections, with important differences in epidemiology, microbiology, host response, and treatment options across the various species. The severity of an infection caused by NTMB is largely determined by the immune status…
Overview Etiology, Prevalence, and Epidemiology Tuberculosis (TB) is a chronic recurrent contagious infection caused by Mycobacterium tuberculosis. M. tuberculosis is an aerobic, nonmotile, non–spore-forming rod that is highly resistant to drying, acid, and alcohol. It is transmitted person to person…
Etiology, Prevalence, and Epidemiology Pneumonia and influenza represent the eighth leading cause of mortality in the United States, with an estimated 1.3 million hospital admissions yearly attributable to pneumonia in patients older than 65 years. Although pneumonia affects all ages,…
Congenital malformations of the pulmonary vessels include absence or interruption, abnormal sizes, origins, or courses, and abnormal connections of the pulmonary arteries or veins. These abnormalities commonly accompany other congenital pulmonary or cardiac disorders but can occur in isolation. Although…
Congenital lung disease remains a confusing topic owing to ever-changing histopathologic understanding of the various entities and frequent updates to antiquated clinical and pathologic classification schemes. Past classifications have been based on thoracic anatomic structures, dividing lesions into congenital malformations…
Diseases that cause a decrease in lung density result in increased radiolucency (hyperlucency) on chest radiography and decreased attenuation on computed tomography (CT). Decreased lung density may result from obstructive overinflation without lung destruction (e.g., asthma, constrictive bronchiolitis), overinflation with…
Many diseases involve predominantly or exclusively the pulmonary interstitium. The differential diagnosis of the various entities on the chest radiograph and computed tomography (CT) is based on the pattern and distribution of abnormalities and on the presence of associated findings,…
Solitary Lung Nodule or Mass A pulmonary nodule is defined as any pulmonary lesion that is well-defined, discrete, approximately circular, and 3 cm or less in diameter. The term mass is used for lesions greater than 3 cm in diameter. The differential…
Atelectasis is defined as less than normal inflation of all or part of the lung with a corresponding diminution in lung volume. Although the term collapse is often used synonymously with atelectasis, it should be reserved for complete atelectasis. Mechanisms…