The clinical pharmacology of a given drug reflects a multifaceted set of properties that pertain to not only the disposition and action of drugs, but also the response (e.g., adverse effects, therapeutic effects, therapeutic outcomes) to their administration or use.…
Interindividual variability in the response to similar doses of a given medication is an inherent characteristic of both adult and pediatric populations. Pharmacogenetics , the role of genetic factors in drug disposition and response, has resulted in many examples of…
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Dehydration, most often caused by gastroenteritis, is a common problem in children. Most cases can be managed with oral rehydration (see Chapter 366 ). Even children with mild to moderate hyponatremic or hypernatremic dehydration can be managed with oral rehydration.…
Maintenance intravenous (IV) fluids are used in a child who cannot be fed enterally. Along with maintenance fluids, children may require concurrent replacement fluids if they have continued excessive losses, as may occur with drainage from a nasogastric (NG) tube…
Composition of Body Fluids Larry A. Greenbaum Keywords total body water fluid compartments edema intracellular fluid extracellular fluid osmolality hyperglycemia pseudohyponatremia point-of-care testing Total Body Water Total body water (TBW) as a percentage of body weight varies with age ( Fig.…
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Vitamin K is necessary for the synthesis of clotting factors II, VII, IX, and X; deficiency of vitamin K can result in clinically significant bleeding. Vitamin K deficiency typically affects infants, who experience a transient deficiency related to inadequate intake,…
Vitamin E is a fat-soluble vitamin and functions as an antioxidant, but its precise biochemical functions are not known. Vitamin E deficiency can cause hemolysis or neurologic manifestations and occurs in premature infants, in patients with malabsorption, and in an…
Rickets Bone consists of a protein matrix called osteoid and a mineral phase, principally composed of calcium and phosphate, mostly in the form of hydroxyapatite . Osteomalacia occurs with inadequate mineralization of bone osteoid in children and adults. Rickets is…