Overview Metastases to bone of tumors from nonosseous primary sites account for the largest percentage of bone tumors. The host bone responds either by osseous resorption (osteolytic), osseous formation (osteoblastic), or often both processes. This chapter will cover the clinical…
Benign “Soft Tissue” Tumors Primary in Bone Schwannoma Definition and Synonyms Schwannoma, also known as neurilemmoma and neurinoma, is a benign nerve sheath tumor that occurs primarily in soft tissue but can also occur primarily within bone or secondarily involve…
Cystic lesions of bone comprise a diverse number of entities, including simple or unicameral bone cyst, aneurysmal bone cyst (ABC), epidermal cyst, and intraosseous ganglion. Simple bone cysts are typically lesions of boys in the long bones and are relatively…
Permeative lesions involving the bone represent many different disease processes and radiographically may mimic one another. The permeative lesions discussed in this chapter represent a diverse group that include benign tumors, malignant tumors, a variety of histiocytic disorders, hematolymphoid-derived tumors…
Vascular tumors of bone are defined as a neoplastic proliferation of endothelial cells that are biologically benign or malignant. This is a heterogeneous group of tumors; it includes a wide variety of different clinicopathologic entities whose biological potential ranges from…
Fibro-osseous Lesions Fibrous Dysplasia Overview Fibrous dysplasia of bone was historically thought to be a developmental anomaly of fibrous tissue and bone but is now known to be secondary to defined mutations in the GNAS gene. Histologically, the osseous component…
Many bone tumors contain large numbers of osteoclast-like giant cells. However, two lesions have many overlapping histologic findings and may pose a particularly difficult problem in differential diagnosis. These lesions are conventional giant cell tumor of bone and giant cell…
The vast majority (greater than 85%) of skeletal chondrosarcomas are conventional chondrosarcomas, which is a family constituted of primary central chondrosarcoma, primary peripheral chondrosarcoma, secondary central chondrosarcoma, secondary peripheral chondrosarcoma, and periosteal chondrosarcoma. The other entities to be considered in…
Chondroblastoma Definition and Synonyms Chondroblastoma is a benign cartilage-forming neoplasm occurring in the epiphyses of immature long bones. Brief Historical Overview Chondroblastoma was originally called a “calcifying giant cell tumor” by Ewing and “epiphyseal chondromatous giant-cell tumor” by Codman. In…
Juxtacortical lesions of bone are a group of entities with differing histogenesis and pathogenesis that arise in association with the periosteum. Periosteal stromal cells participate in fracture repair, and as such, they are able to differentiate into fibroblastic, osteoblastic, and…