Category Pathology

High-grade prostatic intraepithelial neoplasia (HGPIN)

Definition Proliferation of secretory epithelial cells displaying significant architectural and cytologic atypia within the pre-existing acini and ducts Categorized into low-grade prostatic intraepithelial neoplasia (LGPIN) and high-grade (HGPIN) types Clinical features You’re Reading a Preview Become a Clinical Tree membership…

Prostatic infarct

Definition Area of ischemic stromal and glandular tissue damage typically associated with BPH Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in…

Verumontanum mucosal gland hyperplasia

Definition Benign, small acinar proliferation of the prostatic glands that occurs exclusively in the verumontanum and adjacent prostatic urethra. A potential mimic of prostate adenocarcinoma. Clinical features Epidemiology Older patients (age 47–87) Incidental finding in 14% of radical prostatectomy specimens…

Neuroendocrine cells involving the prostate

Definition Neuroendocrine cells of the prostate are intraepithelial regulatory cells that regulate both growth and differentiation, as well as the exocrine secretory activity of the prostate (part of the amine precursor uptake and decarboxylation [APUD] system of endocrine-paracrine cells). These…

Mucin cell metaplasia

Definition Replacement of the normal secretory epithelium of the prostatic ducts and acini with goblet cells. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log…

Squamous metaplasia

Definition Replacement of the normal cuboidal/columnar secretory epithelium of the prostatic ducts and acini with benign squamous epithelium. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a…

Urothelial metaplasia

Definition Replacement of the benign cuboidal to columnar secretory epithelium of the prostatic acini and distal ducts with benign urothelium. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you…

Basal cell hyperplasia

Definition Proliferation of basal cells ranging from focal incomplete involvement of the prostatic glands to florid growth completely lacking luminal cells. Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become…

Hyperplasia of mesonephric remnants

Definition Rare benign lesion characterized by tubular or acinar proliferation of mesonephric remnants Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in…

Clear cell cribriform hyperplasia

Definition A form of benign prostatic hyperplasia characterized by proliferation of benign glands with cribriform architecture, typically in the transition zone of the prostate. Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy…