Category Pathology

Squamous cell carcinoma, verrucous

Definition A subtype of well-differentiated squamous cell carcinoma (SCC) with broad papillary fronds and pushing base; no apparent association with HPV infection Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles…

Lymphoepithelioma-like carcinoma

Definition HPV-related poorly differentiated squamous cell carcinoma morphologically similar to its nasopharyngeal counterpart, characterized by an intense inflammatory response surrounding tumor nests Clinical features Epidemiology Rare variant with only a few cases reported Associated with HPV infection; unlike its nasopharyngeal…

Clear cell squamous cell carcinoma

Definition HPV-related penile squamous cell carcinoma characterized by an aggressive clinical behavior and a clear cell morphology Clinical features Epidemiology Rare, with only a few cases reported You’re Reading a Preview Become a Clinical Tree membership for Full access and…

Squamous cell carcinoma, warty-basaloid

Definition HPV-related squamous cell carcinoma composed of variable proportions of warty and basaloid carcinomas, either separately or intermingled. Clinical features Epidemiology Relatively frequent variant, its epidemiological features similar to other HPV-related penile tumors such as pure warty and basaloid carcinomas…

Penile warty (condylomatous) carcinoma

Definition A form of squamous carcinoma with exophytic and papillomatous growth pattern resembling condylomas but with malignant cytological features Strongly associated with high-risk human papillomavirus infection Clinical features Epidemiology 5%–10% of penile carcinomas and 20%–30% verruciform tumors Most commonly involves…

Squamous cell carcinoma, papillary-basaloid

Definition HPV-related squamous cell carcinoma characterized by exophytic papillae lined by basaloid cells, a variant of basaloid carcinoma Clinical features Epidemiology Unusual tumors, with only a few reported cases Patients with invasive tumors are older compared to those with noninvasive…

Basaloid squamous cell carcinoma

Definition An aggressive variant of squamous cell carcinoma (SCC) with basaloid features; HPV-related Clinical features Epidemiology Accounts for 5%–10% of penile SCC Most patients are 50–59 years old Associated with HPV (HPV16 most common) You’re Reading a Preview Become a…

Squamous cell carcinoma of the penis, usual type

Definition Invasive squamous cell carcinoma (SCC) with a varying degree of keratinization that cannot be classified as other histologic subtypes morphologically; also termed typical, conventional, or SCC, not otherwise specified (NOS) Clinical features You’re Reading a Preview Become a Clinical…

Differentiated penile intraepithelial neoplasia

Definition Non-HPV-related premalignant precursor lesion of the penis characterized by cytologic atypia and abnormal epithelial maturation in the squamous epithelium lining the glans, coronal sulcus, or foreskin, with no extension beyond the basal lamina. Clinical features Epidemiology Similar to invasive…