Category Neurology

Memantine

Quick Start: Memantine Mechanism of action and cognitive benefit Memantine (generic and Namenda extended-release [XR]) has two mechanisms of action: (1) modulating glutamate and (2) enhancing dopamine transmission. It improves attention, alertness, apathy, and global functioning. Indications and recommendations Memantine…

Cholinesterase Inhibitors

Quick Start: Cholinesterase Inhibitors Mechanism of action and cognitive benefit Cholinesterase inhibitors increase the concentration of acetylcholine at the synapse and improve memory, attention, mood, and behavior. Cholinesterase inhibitors are efficacious and well tolerated. Indications and recommendations For Alzheimer’s disease…