General information Aldehydes such as formaldehyde, glyoxal, and glutaral (glutaraldehyde) are used as solutions and vapors for disinfection and sterilization. They are irritating and sensitizing and cause contact dermatitis in health-care workers [ ]. Exposure to formaldehyde occurs in certain…
See also Hair dyes , Ocular dyes General information The US Federal Food, Drug and Cosmetic Act (1938) [ ] defined three classes of certifiable colors: 1. FD&C colors: for use in coloring food, drugs, and cosmetics. 2. D&C colors:…
See also Factor Xa inhibitors, direct General information Fondaparinux and idraparinux are indirect factor Xa inhibitors. Fondaparinux is a synthetic pentasaccharide that mimics the site of heparin that binds to antithrombin III and inhibits factor Xa activity, which in turn…
General information Fomivirsen (ISIS 2922) is an antisense oligonucleotide that specifically inhibits replication of human cytomegalovirus. It has been developed for intravitreal administration to treat cytomegalovirus retinitis in patients with AIDS. You’re Reading a Preview Become a Clinical Tree membership…
General information The first gonadotropins available for clinical use were extracted from the urine of postmenopausal women. Human menopausal gonadotropin (hMG) is in limited supply and contains other proteins, which may be allergenic, as well as luteinizing hormone. Purified preparations…
See also Vitamins General information Folic acid (pteroylglutamic acid) is a vitamin of the B group, whose Average Dietary Requirement in adults has been set at 140 micrograms/day, with a Population Reference Intake of 200 micrograms Red cell folate concentrations…
See also Selective serotonin re-uptake inhibitors (SSRIs) General information Fluvoxamine is a non-sedating antidepressant with fewer anticholinergic adverse effects than clomipramine or imipramine [ ]. Major adverse reactions, as with other SSRIs, include nausea and vomiting. It has a half-life…
See also HMG coenzyme-A reductase inhibitors General information It has been suggested that the pharmacokinetics of fluvastatin, including extensive biliary excretion and absence of circulating active metabolites, might be associated with a low incidence of systemic adverse reactions compared with…
See also Antiandrogens General information Flutamide is a non-steroidal antiandrogen that is used to treat prostatic cancer. Its most common adverse reactions are liver damage and photosensitivity. Drug studies Comparative studies Prostate cancer Although flutamide is sufficiently well tolerated in…
General information Flurotyl, a hexafluorinated ether, has been used as a therapeutic inhalational convulsant in psychiatry [ ]. Its intravenous use in a polyethylene glycol solution has been discontinued because of possible renal damage. In most Western and North American…