General information The genera in the family of Gentianaceae ( Table 1 ) include centaury and various types of gentian. Table 1 Genera of Gentianaceae Bartonia (screwstem) Centaurium (centaury) Cicendia (cicendia) Enicostema (whitehead) Eustoma (prairie gentian) Frasera (green gentian) Gentiana…
See also Aminoglycoside antibiotics General information Gentamicin is well established for the treatment of several bacterial infections, especially those caused by Gram-negative bacteria, including Pseudomonas aeruginosa , Klebsiella species, and Serratia marcescens . In adults, it is usually given in…
See also Antifungal azoles [for systemic use] General information Genaconazole is an N-substituted triazole with a wide antifungal spectrum. Its absorption is slow, with peak concentrations 2–4 hours after a single dose and mean peak concentrations markedly higher after 16…
See also Monoclonal antibodies General information Gemtuzumab ozogamicin (Mylotarg) consists of a humanized anti-CD33 monoclonal antibody conjugated to the cytotoxic enediyne antibiotic calicheamicin. It has been used to treat a subset of patients with acute myeloid leukemia in association with…
See also Fluoroquinolones General information Gemifloxacin is a fluoroquinolone that has enhanced affinity for topoisomerase. Compared with other fluoroquinolones, gemifloxacin was the most potent against penicillin-intermediate and penicillin-resistant pneumococci, methicillin-susceptible and methicillin-resistant Staphylococcus epidermidis isolates, and coagulase-negative staphylococci [ ,…
See also Prostaglandins General information Gemeprost is an analogue of PGE 2 . Vaginal gemeprost is effective in inducing first and second trimester abortion and in cervical priming before vacuum aspiration. Pyrexia, vomiting, and diarrhea were experienced in 20% of…
See also Cytotoxic and immunosuppressant drugs General information Gemcitabine is an S-phase-specific pyrimidine nucleoside analogue of deoxycytidine (2',2'-difluorodeoxycytidine) that is structurally similar to cytosine arabinoside. It has been used to treat metastatic urothelial carcinoma of the bladder, pancreatic cancer, and…
General information Gefitinib is an anilinoquinazoline derivative, the first agent to have been introduced as a potent inhibitor of EGFR tyrosine kinase for the treatment of advanced non-small-cell lung cancer refractory or resistant to cytotoxic chemotherapy. Case series have shown…
See also Fluoroquinolones General information Gatifloxacin is an 8-methoxyfluoroquinolone with enhanced activity against Gram-positive, atypical agents, and some anerobes, and broad-spectrum activity against Gram-negative bacteria [ ]. It is bactericidal and produces a post-antibiotic effect in Gram-positive and Gram-negative bacteria.…
See also Fluoroquinolones General information Garenoxacin (T-3811ME, BMS-284756) is a des-F(6) quinolone that is effective in vitro against a wide range of clinically important pathogens, including Gram-positive and Gram-negative aerobes and anaerobes [ ]. Drug studies You’re Reading a Preview…