General information Piroxicam was the first of the oxicam compounds, and is by far the most widely used. It is an inhibitor of prostaglandin synthesis and platelet aggregation. Its long half-life (36–48 hours) allows it to be given in a…
General information Piritrexim is a lipid-soluble analogue of methotrexate that has been used to treat methotrexate-resistant tumors [ ], including recurrent and metastatic head and neck cancers [ ], soft-tissue sarcomas [ ], non-small cell lung cancers [ ], metastatic…
General information Piridoxilate, an equimolar mixture of glyoxylic acid and pyridoxine, is marketed in a few countries (for example France) for peripheral arterial occlusive disease and functional venous disorders [ ], including vascular ulcers [ , ]. The supposed rationale…
General information Piribedil is a piperazine derivative, a non-ergot dopamine receptor agonist, whose pharmacology is unusual, in that it is an agonist at D 2 and D 3 receptors and an α 2 -adrenoceptor agonist. It has been used for…
General information Piretanide is structurally related to furosemide, with diuretic and kinetic properties very similar to those of furosemide and bumetanide [ ]. Its potency lies somewhere between the two. As with some other diuretics, attempts have been made to…
General information Pirenzepine is an anticholinergic drug with selective effects on muscarinic M 1 receptors, although there is also evidence that it can be an antagonist at M 2 receptors as well. It inhibits gastric acid secretion in the stomach,…
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General information Piracetam is a so-called “nootropic” drug, one of a class of drugs that affect mental function [ ]. In healthy volunteers it improves the higher functions of the brain involved in cognitive processes, such as learning and memory.…
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General information Piperazine is an antihelminthic drug that selectively blocks the neuromuscular cholinergic receptors of worms. It is readily absorbed, but has a highly variable half-life. The adult oral dose of 4 g of piperazine hydrate has been used extensively…