See also Antifungal azoles [for systemic use] General information Ravuconazole is an antifungal azole, similar in structure to fluconazole. It has a long half-life suitable for once-daily dosing. You’re Reading a Preview Become a Clinical Tree membership for Full access…
General information Rasburicase is recombinant urate oxidase, which causes the breakdown of uric acid to 5-hydroxyisourate, which is further broken down to allantoin. Although there is a gene for urate oxidase in human, it is non-functional, and purine catabolism therefore…
General information Rasagiline is a propargylamine that irreversibly and selectively inhibits monoamine oxidase type B and is 5–10 times more potent than selegiline. Its pharmacology, clinical pharmacology, clinical efficacy, and adverse reactions have been reviewed [ , ]. Rasagiline is…
General information Rapacuronium, an aminosteroid non-depolarizing neuromuscular blocking agent with a rapid onset and a comparatively short duration of action [ , ], was withdrawn from the US market in March 2001 and subsequently worldwide. The manufacturers informed the FDA…
General information The genera in the family of Ranunculaceae ( Table 1 ) include anemone, buttercup, columbine, hellebore, larkspur, marsh marigold, and pasque flower. Table 1 Genera of Ranunculaceae Aconitum (monkshood) Clematis (leather flower) Kumlienia (false buttercup) Actaea (baneberry) Consolida…
General information Ranolazine is a piperazine derivative approved for the treatment of chronic angina [ ]. It is thought to act by shifting myocardial energy metabolism away from free fatty acids and towards glucose as a substrate for production of…
See also Histamine H 2 receptor antagonists General information Ranitidine is a histamine H 2 receptor antagonist. Compared with cimetidine, it inhibits hepatic metabolism of other substances only to a very slight extent and is not antiandrogenic. In most other…
Ranibizumab is a specific, affinity-mature, recombinant, humanized, antivascular endothelial growth factor-A (anti-VEGF-A) antibody fragment, which binds all isoforms of VEGF-A, rendering them inactive; it is effective in the treatment of age-related macular degeneration after intravitreal injection [ ]. Drug studies…
General information Ramoplanin was the first in a new class of antimicrobials to reach clinical trials [ ]. It is a glycolipodepsipeptide produced by the fermentation of Actinoplanes species [ ]. Ramoplanin blocks bacterial cell wall biosynthesis by interfering with…
See also Angiotensin-converting enzyme inhibitors General information Ramipril is an ACE inhibitor, a prodrug that is rapidly hydrolysed after absorption to its active metabolite ramiprilat. It has been used in patients with hypertension, heart failure, and myocardial infraction. Organs and…