Risk Autoimmune disorders (SLE, RA, scleroderma, cold agglutinin disease). Lymphoproliferative disorders (CLL, NHL). Prosthetic heart valves (ball-and-cage, and bileaflet valves). Usually subclinical, but can be severe in up to 15% of pts. Family history of hemoglobinopathies or RBC membrane defects…
Risk Incidence in USA: 5%; incidence in surgical population: 5% to 75%. Historically thought to be due to chronic infectious, inflammatory, or malignant conditions. Now known to occur with severe trauma, DM, aging, and acute immune activation. More than 130…
Risk Incidence in USA: 2000 new cases Per million up to age 9. Southeast Asia and South Africa have 10-20 times higher incidence. Within USA, related to agricultural areas or petrochemical industry and chemical exposures. Perioperative Risks Infection Hemorrhage LV…
Risk Lifetime prevalence of anaphylaxis is 0.05% to 2%, most common triggers being food, stings, and iatrogenic causes. Occurs in approximately 1 in 10,000 to 1 in 20,000 anesthetic procedures, and 1 in 6500 administrations of neuromuscular blocking agents (NMDAs).…
Risk Estimated incidence of 1-3:100,000. Mean age of onset is in the 60s, but ALS can occur as early as the 20s. Disease duration is approximately 3 y from the time of diagnosis to death. While there is slight male…
Risk Incidence in USA: 1:100,000 Race with highest prevalence: Unknown Perioperative Risks Increased risk of periop renal failure, cardiomyopathy (arrhythmias and ventricular dysfunction), bleeding from coagulopathy Autonomic neuropathy Worry About Signs of CHF Dysrhythmias Decreasing urine output Overview Extracellular deposition…
Risk Risk factors include: advanced maternal age (>35 y); cesarean delivery; placenta previa; meconium; intrauterine fetal demise; placental abruption; meconium staining of the amniotic fluid; chorioamnionitis; and macrosomia. True incidence is unknown but estimated to occur in 2 to 8…
Risk One of the most common inherited disorders (1 in 2500 in case of European ancestry; uncommon in Asians) Less than 10% of individuals with AAT deficiency are currently identified. AAT deficiency is the most common genetic cause of liver…
Risk Incidence in USA: 5% of adults are allergic to one or more drugs. During surgery, the risk of anaphylaxis is ∼1:2500 to 1:20,000 depending on the agent, with a mortality rate of 4%. Females > males (1.6:1). Perioperative Risks…
Risk Incidence in USA: 10% of Americans, incl physicians, will abuse alcohol at some point in their lives. 1:5 surgical pts has some form of alcohol use disorder. Third leading cause of death and disability, incl 30% of traffic fatalities.…