Category Anesthesia

Topical Analgesics

In contrast to the use of a systemic analgesic, the use of a topical analgesic may result in pain relief without the requirement for notable systemic absorption. In certain situations, and with specific agents (i.e. nitroglycerine, fentanyl, clonidine), transdermal application…

Cannabinoids for Pain Management

Key Points The endocannabinoid system is a complex biologic system composed of endogenous CBR and their respective agonists. It is involved in the regulation of multiple physiologic and cognitive processes in the human body to maintain homeostasis. Endocannabinoids are endogenous…

Skeletal Muscle Relaxants

Key Points There are three broad classes of muscle relaxants: antispasmodic, antispasticity, and combination agents. Muscle relaxants may treat muscle spasticity in two manners. First, they can modify the stretch reflex arc, either by reducing the excitatory signals or by…

Adjunct Medications for Pain Management

Treatment of chronic pain involves understanding the delicate interplay of nociceptive, neuropathic, and nociplastic mechanisms involved in any given pain syndrome’s pathophysiology. Research into the underlying pathways for chronic pain has provided the mechanistic basis to utilize numerous non-opioid medications…