General information Dantrolene, a hydantoin derivative, is well established in clinical practice, being of greatest value for the reduction of clonus and involuntary muscle spasms [ , ]. The recommended oral doses for the treatment of spastic conditions are 75–400…
General information Danazol is a weak androgen and can thus exert the adverse effects of androgens, but because it inhibits LH and FSH secretion it can also elicit menopausal-like symptoms. However, from time to time it has other types of…
General information Danaparoid is a low molecular heparinoid consisting of a mixture of sulfated glycosaminoglycans (heparan, dermatan, and chondroitin sulfates). It has an antithrombotic effect via antithrombin III-mediated inhibition of factor Xa and to a lesser extent through inhibition of…
General information Dalbavancin (BI 397) is a semi-synthetic derivative of A40926, a glycopeptide with a structure related to that of teicoplanin [ , ]. Dalbavancin is more active against Streptococcus pneumoniae than conventional glycopeptides are, and its activity against Staphylococcus…
See also Cytotoxic and immunosuppressant drugs General information Dactinomycin (actinomycin D) is used to treat cancers in children, in particular Wilms’ tumor. It has similar adverse effects to doxorubicin. You’re Reading a Preview Become a Clinical Tree membership for Full…
See also Monoclonal antibodies General information Daclizumab, a humanized antibody directed against the alfa chain of the interleukin-2 receptor, has been used for initial immunosuppression in transplant patients. In a phase III trial in 275 patients who received ciclosporin, glucocorticoids,…
See also Cytotoxic and immunosuppressant drugs General information Dacarbazine is converted to an active metabolite that is thought to be an alkylating agent. It has been used to treat metastatic melanoma and, in combination regimens, soft-tissue sarcomas and Hodgkin’s disease.…
General information Dabigatran etexilate is a prodrug of dabigatran, a specific, competitive, reversible inhibitor of thrombin. Dabigatran etexilate is rapidly absorbed after oral administration and converted to dabigatran. Its half-life is about 8 hours after a single dose and 14–17…
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See also Alkylating cytostatic agents—nitrosoureas and N -lost derivatives ; Platinum-containing cytostatic drugs General information Cytotoxic drugs generally have both anticancer and immunosuppressive properties, while immunosuppressant drugs have more specific immunosuppressive effects, although this is a somewhat arbitrary distinction. Monoclonal…