General information Diaminopyridine (3,4-diaminopyridine), now also known as amifampridine, blocks calcium-dependent potassium channels and prolongs the duration of the action potential at motor nerve terminals; this enhances calcium influx into nerve endings and causes release of acetylcholine [ ]. It…
General information Dialysis fluids are solutions of electrolytes formulated in concentrations similar to those of extracellular fluid or plasma. They contain, or may contain: sodium; chloride; bicarbonate or lactate; calcium; magnesium; potassium; glucose; amino acids; icodextrin. Dialysis fluids are provided…
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General information The most frequent adverse reactions to dextropropoxyphene are dizziness, sedation, and nausea and vomiting. Other reported reactions include constipation, abdominal pain, skin rashes, light-headedness, headache, weakness, euphoria, dysphoria, minor reversible visual disturbances, and liver dysfunction [ ]. A…
General information Dextromethorphan is the dextrorotatory isomer of the synthetic opioid levorphanol [ ]. It is a non-competitive antagonist at N -methyl- d -aspartate (NMDA) receptors. It also binds to CNS sigma opioid binding sites [2] and increases 5-HT concentrations…
General information Dextrans are mixtures of polymerized glucose molecules, mostly alpha-1,6-glucans, of variable molecular weight from 1 to 110 kDa. Infused dextran is mainly eliminated unmodified by the kidney at a rate of 50% in the first 24 hours and…
General information The α 2 -adrenoceptor agonist dexmedetomidine has potent sedative and analgesic-sparing properties. In therapeutic doses it does not cause respiratory depression, making it attractive for infusion sedation. However, it causes reduced sympathetic outflow, which might cause untoward hemodynamic…
General information Dexloxiglumide is a cholecystokinin CCK 1 receptor antagonist [ ]. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
General information See also Non-steroidal anti-inflammatory drugs (NSAIDs) Dexketoprofen is the dextrorotatory stereoisomer of ketoprofen. The analgesic effect of ketoprofen is due to the S(+)-enantiomer (dexketoprofen), while the R(−)-enantiomer has no analgesic activity [ ] but may be ulcerogenic […