See also Non-nucleoside reverse transcriptase inhibitors (NNRTIs) General information Delavirdine is a non-nucleoside reverse transcriptase inhibitor, which is dosed three times daily. No food restrictions apply. It is metabolized mainly by CYP3A, and so interactions with other drugs that use…
General information Defibrotide is a polydeoxyribonucleotide extracted from mammalian organ [ ]. Its antithrombotic activity is partly ascribed to enhancement of eicosanoid metabolism, in particular increased release of prostacyclin, with ensuing vasodilatation and inhibition of platelet aggregation. An additional mechanism…
General information Deferoxamine is a polyhydroxamine acid with specific affinity for iron and, less strongly, aluminium. It is a naturally occurring siderophore produced by Streptomyces pilosus. Uses Deferoxamine is used in the treatment of acute iron poisoning and in iron…
General information Deferiprone is an alpha-ketohydroxypyridine compound with metal-chelating properties [ ]. It is absorbed within minutes after oral administration and reaches maximum blood concentrations within 1 hour. It has a half-life of 1–2 hours, and is almost completely undetectable…
General information Deferasirox (ICL670), a hydroxyphenyltriazole derivative, is a tridentate selective iron chelator and an N-substituted bis-hydroxyphenyltriazole compound for oral use, available as 125, 250, and 500 mg tablets and administered in a daily dose of 20–50 mg It is…
General information Decitabine (5-aza-2′-deoxycytidine) is structurally very similar to azacitidine [ ]. Both drugs have promising activity against acute myeloblastic leukemia and myelodysplastic syndrome. In addition, decitabine has significant activity against chronic myeloid leukemia. It is rapidly metabolized in the…
General information Decamethonium, a depolarizing neuromuscular blocker, is little used nowadays. A dose of 3 mg provides adequate relaxation for intra-abdominal surgery for about 15 minutes, supplements being required at intervals of 10–30 minutes. It is not as rapid in…
General information Dasatinib (BMS-354825), a thiazole carboximide derivative, is structurally related to imatinib. It targets src kinase and imatinib-resistant bcr–abl kinase and has impressive activity in patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia [ , ].…
General information Daptomycin is a novel lipopeptide antibiotic, an inhibitor of lipoteichoic acid synthesis, with potent bactericidal activity against most clinically important Gram-positive bacteria, including resistant strains [ , ], such as meticillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci and was…
General information Dapsone is 4,4-diaminodiphenylsulfone (DDS, avlosulfone, disulfone) [ ]. It is a bacteriostatic antileprosy drug with a sulfonamide-like structure. The dosage should be 50–100 mg/day in adults [ ]. In children aged 3–5 years, the dosage should be reduced…