See also Nucleoside analogue reverse transcriptase inhibitors (NRTIs) General information Didanosine (2′,3′-dideoxyinosine, ddI) is a purine analogue reverse transcriptase inhibitor. The major clinical adverse effects reported during the first years of use of didanosine were acute pancreatitis and a painful…
See also Anticholinergic drugs ; Doxylamine General information Dicycloverine, in the doses generally used (up to 450 mg/day), is of disputed value. It may have a non-specific relaxant action on the gastrointestinal muscle. The evidence of its effects is meager…
General information The overall incidence of adverse reactions to diclofenac is about 30%, but less than 1% of patients have to have treatment withdrawn for this reason. The manufacturers’ analysis of 1966 adverse effects in 987 patients over about 6…
General information Dichlorophen is an antihelminthic drug that was used in the treatment of tapeworm infections but has been superseded by praziquantel and niclosamide. It also has antifungal and antibacterial activity and has been used topically in the treatment of…
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General information Dibromopropamidine in a cream base is used to treat herpesvirus skin lesions. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
General information Dibenzepin is a 6,7,6 tricyclic compound of the dibenzodiazepine type. A comparison with imipramine was said to show equal efficacy; adverse reactions were comparable in type and degree [ ]. You’re Reading a Preview Become a Clinical Tree…
General information Diazoxide is a direct vasodilator that acts on vascular smooth muscle to produce systemic vasodilatation. As a result there is baroreceptor-mediated activation of the sympathetic nervous system and the renin–angiotensin system. Vasodilators (as monotherapy) are associated acutely with…
General information Diazepam produces less sedation in cigarette smokers, and higher doses may be required for the same sedative or anxiolytic effect. Owing in part to its continued widespread use, several unusual adverse effects of diazepam continue to be reported.…
General information Heroin is a potent opioid that offers no substantial advantages over morphine. In the UK it is the preferred parenteral opioid for subcutaneous administration to cachectic cancer patients, because of its high solubility. The prevalence of heroin as…