See also Antihistamines General information Diphenylpyraline is an antihistamine, a piperidine derivative [ ], with antimuscarinic and sedative properties. It has been used to treat allergic and vasomotor rhinitis [ ], chronic urticaria [ ], and the symptoms of the…
General information Diphenoxylate is a synthetic compound designed to have the antidiarrheal effects of the opiates, but it also retains some less desirable opiate effects. It is generally combined with atropine, as co-phenotrope, which was originally added to the formulation…
See also Antihistamines General information Diphenhydramine is a typically sedating first-generation antihistamine. It is still widely used, mainly in over-the-counter products, often in combination with other drugs. Diphenhydramine inhibits CYP2D6 and can cause clinically important interactions with many CYP2D6 substrates,…
General information Diphencyprone (diphenylcyclopropenone) is a potent sensitizing chemical used to induce a contact dermatitis of the scalp in the topical immunotherapy of alopecia areata [ ] and warts [ ]. Drug studies You’re Reading a Preview Become a Clinical…
See also individual agents General information Sitagliptin ([2R]-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl]-1-[2,4,5-trifluorophenyl]butan-2-amine) [ ] was the first inhibitor of dipeptidyl peptidase type 4 (DPP-4) to have received a licence in the UK (in 2007). Other are linagliptin, saxagliptin, and vildagliptin. DPP-4 is an enzyme…
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Agathosma betulina (buchu) contains diosmin (also known as venosmine), a bioflavonoid, and a synthetic form of diosmin is also available. Hidrosmin is 3',5-di-O-(2-hydroxyethyl)diosmin. Diosmin is marketed as Daflon and Detralex, which contain 90% diosmin plus 10% hesperidin, a flavanone glycoside…
See also Prostaglandins General information Dinoprostone is PGE 2 available for exogenous administration. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
General information Dinitrochlorobenzene is a potent sensitizer that has been applied topically in the evaluation of delayed hypersensitivity. It has also been used as an immunostimulant in conditions such as leprosy, HIV infection, and some forms of cancer, and to…
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