General information Dofetilide is a pure Class III antidysrhythmic drug, without actions of any other class. It was developed following the observation that bis(arylalkyl)amines with methanesulfonamido moieties on both aryl groups prolong the cardiac action potential without significantly altering the…
See also Cytotoxic and immunosuppressant drugs General information Docetaxel is a taxane that is used in combination with doxorubicin in the treatment of metastatic breast cancer and as a single agent in metastatic lung cancer. Organs and systems Respiratory Interstitial…
General information Dobutamine is a relatively selective β 1 -adrenoceptor agonist with only slight β 2 – and α-adrenoceptor activity. It has been developed as a positive inotropic agent that is less vasoconstrictive than high doses of dopamine. Organs and…
General information Diuretics are among the most widely used drugs, particularly for the treatment of hypertension and of various conditions associated with sodium retention. Considering the widespread use of diuretics over a long period (chlorothiazide was introduced in 1957) their…
See also Diethyldithiocarbamate General information Oxidation of sodium diethyldithiocarbamate gives a disulfide, also called thiuram disulfide or disulfiram. Disulfiram has been widely used since the late 1940s to facilitate abstinence from alcohol [ ]. Concomitant use of alcohol during disulfiram…
See also Antidysrhythmic drugs General information The use, clinical pharmacology, and adverse effects of disopyramide have been reviewed [ , ]. Drug studies Observational studies Because of its negative inotropic effect, disopyramide reduces the left ventricular outflow gradient and improves…
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See also Macrolide antibiotics General information Adverse reactions to dirithromycin were studied in 4263 patients [ ]. There was abdominal pain in 5.6%, diarrhea in 5.0%, and nausea in 4.9%. Headache was relatively common (4.5%). In 63% of cases the…
General information Dipyridamole inhibits platelet aggregation by inhibiting platelet cyclic AMP phosphodiesterase, potentiating adenosine inhibition of platelet function by blocking adenosine reuptake by vascular and blood cells and breakdown of adenosine, and by potentiating prostaglandin I 2 antiaggregatory activity and…
See also Vaccines ; Pertussis vaccines General information Diphtheria vaccine contains diphtheria toxoid carried on aluminium hydroxide or calcium phosphate. Single antigen products are available only for cases in which combined antigens should not be used. The formulations used in…