General information Cholinesterase inhibitors increase parasympathetic nervous system (cholinergic) activity indirectly by inhibiting acetylcholinesterase, thereby preventing the breakdown of acetylcholine. They are only effective in the presence of acetylcholine. They are listed in Table 1 . Table 1 Acetylcholinesterase inhibitors…
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See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Despite claims that aceclofenac is a COX-2 selective inhibitor, experience shows that its adverse effects profile is similar to that of the non-selective NSAIDs. Organs and systems You’re Reading a Preview Become…
See also Antidysrhythmic drugs General information Acecainide (N-acetylprocainamide) is the main metabolite of procainamide, and it has antidysrhythmic activity [ ]. However, in contrast to procainamide, which has Class Ib activity, the main action of acecainide is that of Class…
See also Beta-adrenoceptor antagonists General information Acebutolol is a beta-adrenoceptor antagonist with membrane-stabilizing activity that is sometimes cited as being cardioselective but has considerable effects on bronchioles and peripheral blood vessels. Organs and systems Respiratory Bronchiolitis obliterans has been attributed…
See also Herbal medicines General information The family of acanthaceae includes about 250 genera, including Andrographis (false waterwillow), Ruellia (wild petunia), and Ancistranthus (desert honeysuckle). You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…
General information Acamprosate (calcium acetylhomotaurinate) has been postulated to act by restoring the alcohol-induced neurotransmission imbalance of inhibition–excitation inputs believed to underlie alcohol dependence [ , ]. The molecular structure of acamprosate explains its specificity toward the basic molecular mechanisms…
General information Abiraterone acetate is a potent inhibitor of cytochrome P450 C17 (CYPC17) [ ]. It is being used for the treatment of castration-resistant prostate cancer. It was first approved for use by the Food and Drug Administration (FDA) in…
General information Abetimus is a selective immunomodulator for the treatment of systemic lupus erythematosus. It induces tolerance in B lymphocytes directed against double-stranded DNA by cross-linking surface antibodies. It also reduces serum double-stranded DNA antibodies and splenic double-stranded DNA antibody-producing…
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