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Bromhexine is taken orally or by aerosol and reduces sputum viscosity as measured ex vivo. Although it is still used empirically by some physicians, there have been no controlled studies showing a significant improvement in clinical status or lung function. Administration by inhalation aerosol or nasal spray produces a local expectorant/mucolytic effect [ ]. Inhaled bromhexine (Paxirasol) reduces the amount of sputum, but does not reduce symptoms [ ].
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