Definition A variant of renal cell carcinoma defined by loss of protein expression of fumarate hydratase (FH) on immunohistochemistry; the majority of tumors occur in the setting of hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC) with germline mutation in…
Definition A renal cell carcinoma (RCC) subtype comprising large pale and/or eosinophilic cells with prominent cell borders, irregular nuclei, and perineuclear halos Clinical features Epidemiology Five percent of RCCs Mean age, 50–60 years (range, 30–90 years) Male-to-female ratio, 1.5:1 You’re…
Definition A histological subtype of renal cell carcinoma (RCC) with predominant tubulopapillary architecture and characteristic genetic changes; 1.5 cm is the size threshold for papillary RCC; smaller low-grade lesions without fibromuscular pseudocapsule are classified as papillary adenoma. Clinical features Epidemiology…
Definition A tumor composed of multiple cysts lined by low-grade clear cells and no solid or expansile nodules Clinical features Epidemiology Less than 5% of clear cell tumors Age and gender distribution similar to clear cell renal cell carcinomas Usually…
Definition The most common histological subtype of renal cell carcinoma (RCC), composed of cells with clear or eosinophilic cytoplasm and a prominent but delicate vascular network Clinical features Epidemiology Two percent of all malignancies and approximately 70% of RCCs Primarily…
Definition Benign renal epithelial neoplasm composed of large round-to-polygonal cells with abundant mitochondria-rich eosinophilic cytoplasm Clinical features Epidemiology 4%–8% of adult renal epithelial neoplasms in surgical pathology Wide range of age distribution with a peak incidence in the seventh decade…
Definition Epithelial tumor with tubulopapillary architecture, low nuclear grade, and a diameter of 15 mm or less Clinical features Epidemiology Increased incidence with age No gender predilection You’re Reading a Preview Become a Clinical Tree membership for Full access and…
Definition Chronic infection of the renal parenchyma by a specific infectious agent Clinical features Epidemiology Uncommon, but more frequent in immunocompromised patients and transplant recipients. Common bacteria and fungi are the most frequent causative agents during the early post-transplantation period.…
Definition A clinicopathological entity characterized by inflammation in the renal interstitium with various etiologies, often secondary to an allergic reaction to a drug Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…
Definition A clinicopathological entity with pathological changes in the renal tubules when ischemic or toxic injuries affect the kidney Clinical features Epidemiology Acute kidney injury (AKI) is the most common cause of acute renal failure. The precipitating events include ischemic…