Neuroradiology: Spectrum and Evolution of Disease

Toxoplasmosis

Introduction Central nervous system (CNS) toxoplasmosis is an opportunistic infection caused by the intracellular protozoan parasite Toxoplasma gondii . This parasite may be acquired in utero or through the ingestion of infected meat or cat feces, as cats are its…

Herpes Simplex Encephalitis

Introduction Herpes simplex encephalitis (HSE) is the most common cause of fatal sporadic encephalitis worldwide. In adults and older children, most cases of HSE are caused by the herpes simplex virus 1 (HSV-1) virus. Patients initially present with nonspecific neurologic…

Central Pontine Myelinolysis

Introduction Central pontine myelinolysis (CPM) was originally described by . He first detailed the entity in a group of malnourished and alcoholic patients. Further studies and advancement in medicine have shown that CPM most commonly results from the rapid correction…

Wernicke Encephalopathy

Introduction Wernicke encephalopathy (WE) was first described in 1881 by Carl Wernicke as a “superior acute hemorrhagic polioencephalitis.” WE is now recognized as a complication of thiamine (vitamin B1) deficiency and results in the following clinical triad: mental confusion, gait…

Cerebral Amyloid Angiopathy

Introduction Cerebral amyloid angiopathy (CAA) is a microangiopathy defined by progressive deposition of beta amyloid (Aβ) in the walls of distal cortical and leptomeningeal vessels. The resulting small vessel damage can result in hemorrhage, infarction, and/or chronic hypoperfusion, the sequela…

Posterior Reversible Encephalopathy Syndrome

Introduction Posterior reversible encephalopathy syndrome (PRES) refers to a potentially reversible neurotoxic state occurring in association with vasogenic cerebral edema. Although the reported age range varies between 4 and 90 years, most affected patients are in their fourth or fifth…

Subdural Hemorrhage and Posttraumatic Hygroma

Introduction The accurate age determination of a subdural hemorrhage is one of the most common and basic assessments in the setting of head trauma. On computed tomography (CT), the classic descriptions of blood products within the subdural space relate to…

Brain Parenchymal Hematoma Evolution

Introduction Magnetic resonance imaging (MRI) can differentiate between acute, subacute, and chronic hemorrhage because of its sensitivity and specificity to hemoglobin degradation products. Therefore the imaging interpreter is, with proper knowledge, able to estimate the age of a brain parenchymal…