See also Cytotoxic and immunosuppressant drugs General information Floxuridine is a pyrimidine analogue that is used in regional arterial chemotherapy for primary and metastatic malignancies, delivered using an implantable pump. You’re Reading a Preview Become a Clinical Tree membership for…
See also COX-2 inhibitors (coxibs) General information The clinical development flosulide, a COX-2 inhibitor, was discontinued because of nephrotoxicity [ ]. Measurement of renal prostaglandin synthesis did not predict its nephrotoxicity in single-dose and short-term studies [ ]. You’re Reading…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Floctafenine is a 4-aminoquinoline NSAID, closely related to antrafenine and glafenine, and its adverse reactions profile is similar [ ]. Organs and systems You’re Reading a Preview Become a Clinical Tree membership…
See also Antidysrhythmic drugs General information Flecainide is a class Ic antidysrhythmic drug. Its clinical pharmacology, clinical use, and adverse effects and reactions have been reviewed [ ]. Drug studies Observational studies Intravenous flecainide 2 mg/kg over 10 minutes (maximum…
See also Anticholinergic drugs General information Flavoxate is an anticholinergic drug that is used to treat bladder detrusor instability. It can cause all the adverse effects and reactions that would be expected from its anticholinergic action. You’re Reading a Preview…
General information Omega-3 fatty acids are long-chain polyunsaturated fatty acids. The parent fatty acid of this group is alpha-linolenic acid, an essential fatty acid that the body is unable to synthesize; alpha-linolenic acid can be converted in the body to…
See also Immunosuppressants drugs General information Fingolimod (previously FTY720) is an immunomodulator that is used in combination therapy with other immunosuppressant drugs in the prophylaxis of acute rejection after solid organ transplantation and for the treatment of multiple sclerosis. It…
See also Antiandrogens General information Finasteride is a selective inhibitor of 5-alpha-reductase. It thereby reduces prostatic concentrations of dihydrotestosterone and so reduces prostatic size [ ]. It is therefore used to treat benign prostatic hyperplasia [ ] and in the…
General information Fibrin glue is a topical tissue adhesive, a two-component system. One component contains highly concentrated fibrinogen, factor VIII, fibronectin, and traces of other plasma proteins. The other component contains thrombin, calcium chloride, and antifibrinolytic agents such as aprotinin.…
General information Fibrates reduce plasma triglycerides by inhibiting their hepatic synthesis and increasing their catabolism. They reduce the synthesis of triglyceride–very low density lipoprotein (VLDL) by increasing the beta-oxidation of fatty acids in the liver. They increase triglyceride catabolism by…