Additional content is available online at Elsevier eBooks for Practicing Clinicians The pathophysiologic definition of heart failure (HF)—the “inability of the heart to pump blood to the body at a rate commensurate with its needs, or to do so only…
Additional content is available online at Elsevier eBooks for Practicing Clinicians The epidemiology and clinical assessment of patients with heart failure (HF) is reviewed in Chapter 48 , whereas the following chapter will focus on the management of patients with…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Acute heart failure (AHF) is among the most common causes for hospitalization in patients older than 65 years in the developed world. Increasingly, the spectrum of worsening HF is…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Heart Failure Definition and Epidemiology Heart failure (HF) is a complex clinical syndrome resulting from structural and functional impairment of ventricular filling or ejection of blood. While the clinical…
Additional content is available online at Elsevier eBooks for Practicing Clinicians This chapter focuses on the molecular and cellular changes that underlie heart failure with a reduced ejection fraction (HFrEF), with an emphasis on the role of neurohormonal activation and…
Acknowledgment We honor the memory of Dr. Lionel H. Opie who contributed to previous versions of this chapter over the years. Additional content is available online at Elsevier eBooks for Practicing Clinicians Microanatomy of Contractile Cells and Proteins Ultrastructure of…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Each year, almost 800,000 Americans have a stroke, and between 200,000 and 500,000 have a transient ischemic attack (TIA). Data from 2020 show that about 610,000 of these strokes…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Peripheral vascular disease is a general term that includes pathologic processes affecting arteries, veins, and lymphatics (see Chapter 43 ). This chapter focuses on catheter-based endovascular treatment of large-…
Acknowledgment The authors thank Dr. Peter Libby, co-author of this chapter in editions 6 to 10, for his contributions and mentorship. Additional content is available online at Elsevier eBooks for Practicing Clinicians Peripheral artery disease (PAD) generally refers to acute…
Additional content is available online at Elsevier eBooks for Practicing Clinicians The Normal Aorta Anatomy and Physiology The aorta, the largest artery in the body, has thoracic and abdominal components ( Fig. 42.1 ). The thoracic aorta is divided into…