Additional content is available online at Elsevier eBooks for Practicing Clinicians The systemic amyloidoses are a group of diseases characterized by the extracellular deposition of insoluble, misfolded fibrillar proteins in the form of β-pleated sheets, resulting in organ dysfunction. First…
Additional content is available online at Elsevier eBooks for Practicing Clinicians There remains no satisfying universal definition of cardiomyopathy. Even though it is now agreed that myocardial disease secondary to atherosclerotic coronary artery disease (CAD), valvular disease, congenital heart disease,…
Additional content is available online at Elsevier eBooks for Practicing Clinicians The pathophysiologic definition of heart failure (HF)—the “inability of the heart to pump blood to the body at a rate commensurate with its needs, or to do so only…
Additional content is available online at Elsevier eBooks for Practicing Clinicians The epidemiology and clinical assessment of patients with heart failure (HF) is reviewed in Chapter 48 , whereas the following chapter will focus on the management of patients with…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Acute heart failure (AHF) is among the most common causes for hospitalization in patients older than 65 years in the developed world. Increasingly, the spectrum of worsening HF is…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Heart Failure Definition and Epidemiology Heart failure (HF) is a complex clinical syndrome resulting from structural and functional impairment of ventricular filling or ejection of blood. While the clinical…
Additional content is available online at Elsevier eBooks for Practicing Clinicians This chapter focuses on the molecular and cellular changes that underlie heart failure with a reduced ejection fraction (HFrEF), with an emphasis on the role of neurohormonal activation and…
Acknowledgment We honor the memory of Dr. Lionel H. Opie who contributed to previous versions of this chapter over the years. Additional content is available online at Elsevier eBooks for Practicing Clinicians Microanatomy of Contractile Cells and Proteins Ultrastructure of…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Each year, almost 800,000 Americans have a stroke, and between 200,000 and 500,000 have a transient ischemic attack (TIA). Data from 2020 show that about 610,000 of these strokes…
Additional content is available online at Elsevier eBooks for Practicing Clinicians Peripheral vascular disease is a general term that includes pathologic processes affecting arteries, veins, and lymphatics (see Chapter 43 ). This chapter focuses on catheter-based endovascular treatment of large-…