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Aspirin (Acetylsalicylic Acid)


Uses

  • People in USA consume 10,000–20,000 tons annually.

  • Rx for mild and/or moderate pain, fever, arthritis, and prevention of MI.

Perioperative Risks

  • Peptic ulcer disease

  • Plt dysfunction

  • Increased bleeding risk

  • Stroke

  • Interstitial nephritis

  • Reye syndrome

Worry About

  • Displacement of protein-bound drugs (e.g., warfarin, sulfonylureas, thiopental, methotrexate)

  • Potentiation of anticoagulants.

  • Thrombosis secondary to aspirin withdrawal.

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