See also Antidysrhythmic drugs

General information

The pharmacology, clinical pharmacology, clinical uses, efficacy, and adverse effects of aprindine have been extensively reviewed [ ].

The adverse effects of aprindine most commonly affect the central nervous system. However, other less common but serious and potentially fatal adverse effects (neutropenia and liver damage) occur, and these limit its usefulness.

Aprindine is metabolized by CYP2D6, and one would therefore expect interactions with drugs that inhibit this isoenzyme or are metabolized by it.

Drug studies

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