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Lornoxicam
See also Non-steroidal anti-inflammatory drugs (NSAIDs)
General information
Data are insufficient to indicate whether the oxicam NSAID lornoxicam is safer for the gastrointestinal tract than other oxicam derivatives [ ]. Headache, dizziness, and gastrointestinal symptoms are the most frequent adverse effects; clinically significant gastrointestinal events include upper gastrointestinal ulceration, with or without hemorrhage or perforation [ , ]. The profile of drug interactions is similar to the profiles of other NSAIDs [ ].
Organs and systems
Gastrointestinal
Multiple small hemispheric polyps, associated with luminal narrowing, were found in the gastric antrum of a 74-year-old man who had taken lornoxicam [ ]. The polyps consisted of granulation tissue and immature regenerative epithelium. The authors suggested that in the hypoacidic conditions induced by nizatidine, inflammatory polyps could have arisen through rapid and excessive regeneration after gastric mucosal injury due to the NSAID. However, there was no evidence in this case of a cause-and-effect relation.
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